Sep 26, 2022 · The maximum recommended dosage is 60mg/kg per day
Each week, your doctor may increase your daily dose by 5 mg/kg to 10 mg/kg
Depakote initial dose: 750 mg/day PO in divided doses
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Descriptions Valproic acid is used to treat certain types of seizures (epilepsy)
Ordinarily, optimal clinical response is achieved at daily doses below 60 mg/kg/day
• Complex Partial Seizures: Start at 10 to 15 mg/kg/day, increasing at 1 week intervals by 5 to 10
However, the dose is usually not more than 60 mg per kg of body weight per day
intervals by 5 to 10 mg/kg/day to achieve optimal clinical response; if response is not satisfactory, check valproate plasma level; see full prescribing information for conversion to monotherapy (2
• Absence Seizures: Start at 15 mg/kg/day, increasing at 1 week intervals by Initially 600 mg daily in 2–4 divided doses, increased in steps of 150–300 mg every 3 days; usual maintenance 1–2 g daily in 2–4 divided doses, max
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173: Patients with epilepsy on concomitant enzyme- inducing antiepilepsy drugs Usual maintenance dose: 1 to 5 mg/kg/day orally in 1 or 2 divided doses; Maximum dose: 200 mg/day; Usual maintenance dose with valproate alone: 1 to 3 mg/kg/day orally in 1 or 2 divided doses (includes valproic acid and divalproex sodium); exceeding the recommended initial dose; or exceeding the recommended dose
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Depakote DR tablets and Depakote ER tablets are approved to treat manic or mixed episodes related to bipolar disorder in adults
3 mg/kg of body weight given in one dose or two smaller doses each day for 2 weeks
Max dose is 60 mg/kg/day
(Doses exceeding 250 mg must be in divided Serious side effects of Depakote that have been reported include: low platelet count (a type of blood cell involved in blood clotting) hypothermia (low body temperature) high level of ammonia in Find medical information for divalproex sodium on epocrates online, including its dosing, contraindications, drug interactions, and pill pictures
While it is generally agreed that pharmacological treatment beyond an acute response in mania is
A good correlation has not been established between daily dose, serum concentrations, and therapeutic effect
As Depakote ER dosage is titrated upward, concentrations of clonazepam, diazepam, ethosuximide, lamotrigine, tolbutamide, phenobarbital, carbamazepine, and/or phenytoin may be affected [see Drug Interactions ]
The maximum recommended dosage is 60 mg/kg/day (2
Usual maintenance dose
5 mg/kg/day (maximum 300 mg/day in 2 divided doses) 5 to 15 mg/kg/day (maximum 400 mg/day in 2 divided doses) Maintenance dose in patients <30 kg
Maximum dose: 600 mg/day
Depakote affects chemicals in the body that may be involved in causing seizures
In two multiple dose studies, when administered either fasting or immediately before smaller meals, the ER tablet produced an average bioavailability of 81-89% relative to DEPAKOTE DELAYED-RELEASE TABLETS given BID
1) • Pediatric: Children under the age of two years are at considerably higher risk of fatal hepatotoxicity (5
It's occasionally used to prevent migraine headaches